Ikwu ọdịnaya

Ọrụ nyocha EB

DEBRA UK bụ onye kacha enye ego UK nyocha EB, inye onyinye nye ndị na-eme nchọpụta nwere ọkachamara na ngalaba sayensị na ahụike kachasị mkpa maka ezinụlọ ndị bi na EB.

Pọtụfoliyo anyị nke ọrụ nyocha gụnyere ọrụ ụlọ nyocha izizi, nyocha n'ime usoro ọgwụgwọ mkpụrụ ndụ ihe nketa na mkpụrụ ndụ na imeghachi ọgwụ, yana ọrụ na-ebute mgbanwe na enyemaka mgbaàmà maka ọgwụgwọ ọnya na ọgwụgwọ ọrịa kansa.

Nnyocha anyị na-akwado bụ ọkwa ụwa, nke ahụ bụ n'ihi na ọ bụghị naanị na anyị na-akwado ndị sayensị UK na ndị dọkịta mana ndị kacha mma n'ụwa. Ọtụtụ n'ime ọrụ ndị anyị na-akwado na-ejikọta ihe ọmụma na nkà sitere n'aka ndị nchọpụta n'ọtụtụ saịtị nyocha na UK na mba ụwa.

Mmadụ abụọ na-arụ ọrụ nyocha na-atụ aka na mbadamba nkume nke na-egosipụta usoro nke mkpụrụedemede DNA na-acha anụnụ anụnụ na odo odo. Otu onye yi uwe lab.

Usoro mkpụrụ ndụ ihe nketa EBS

Chọpụta mkpa ọ dị ịhazi mkpụrụ ndụ ihe nketa EBS na mmetụta ya na nyocha sayensị.
Mụtakwuo
Onyonyo a na-ahụ anya na-egosi nje bacteria na-acha odo odo n'elu akwụkwọ ndụ akwụkwọ ndụ ederede.

Biofilms na-egbu oge ọgwụgwọ ọnya EB

Chọpụta mmetụta biofilms na ọgwụgwọ ọnya na-egbu oge yana ka nyocha anyị ga-esi lelee nsonaazụ kacha mma.
Mụtakwuo
Ihe atụ nke eriri DNA na-emekọrịta ihe na elu graphene hexagonal, na-egosipụta mmekọrịta molekụla n'azụ grid.

Nnwale mkpụrụ ndụ ihe nketa dị mfe maka ụdị EB niile

Mụta maka ọganihu ọhụrụ na nyocha mkpụrụ ndụ ihe nketa maka ụdị EB niile. Usoro dị mfe maka nsonaazụ ka mma.
Mụtakwuo
Ihe atụ nke eriri DNA abụọ nwere njedebe na-egbuke egbuke megide ndabere gbara ọchịchịrị nwere ngwa na-adịghị mma na atụmatụ sekit.

CRISPR/Cas9 iji rụkwaa mkpụrụ ndụ RDEB

Chọpụta ka ndezi mkpụrụ ndụ CRISPR/Cas9 nwere ike isi rụkwaa mkpụrụ ndụ RDEB ma nwee ike gwọọ ọnya DEB. Mụtakwuo na blọọgụ onye nyocha anyị.
Mụtakwuo
Ihe atụ nke nje na-agbaba ihe mkpụrụ ndụ ihe nketa n'ime cell, na-egosi irighiri nje na-ejikọta na ibufe DNA ma ọ bụ RNA n'ime cell ndị ọbịa.

Imelite nnyefe nke usoro ọgwụgwọ mkpụrụ ndụ RDEB

Usoro ọgwụgwọ mkpụrụ ndụ ọhụrụ maka ọnya RDEB: Nje Virus ọhụrụ sitere n'aka Dr. Ángeles Mencía na CIEMAT.
Mụtakwuo
Profaịlụ akụkụ dị nso nke nwa dina ala, na-ele anya elu, na-elekwasị anya na anya na nku anya ogologo.

Na-ebelata ọnya anya DEB/JEB

Nledo anya na-egbochi ọnya ọhụhụ maka DEB/JEB: Nnyocha iji belata ọnya anya wee weghachi ọhụụ.
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Eserese eserese nke otu eriri DNA

Hickerson 2 (2019)

Hickerson na-enyocha iji Ultrasound dị ka usoro nnyefe maka epidermolysis bullosa simplex Therapy.
Mụtakwuo
Eserese eserese nke otu eriri DNA

Hubbard 1 (2017)

Hubbard na-eduzi ọmụmụ ogologo ogologo oge gbasara ahụike ọkpụkpụ na ndị okenye nwere recessive dystrophic epidermolysis bullosa (RDEB).
Mụtakwuo
Eserese eserese nke otu eriri DNA

Liossi (2014)

Liossi na-eduga otu ndị na-eme nchọpụta iji nyochaa ahụmahụ nke mgbu na ụmụaka nwere EB na ndị mụrụ ha na otú o si emetụta ahụike uche.
Mụtakwuo
Onye nyocha nke yi uwe aka na-acha anụnụ anụnụ na-etinye efere Petri n'okpuru microscope maka nyocha.

PhD: ibelata ọnya na JEB

Chọpụta ka ọgwụ ndị dị adị nwere ike isi nye ahụ efe site na ibelata ọnya na JEB na mmemme PhD ọhụrụ.
Mụtakwuo
Onye yi uwe aka na-acha anụnụ anụnụ na-eji pipette ebufe mmiri mmiri na-acha ọbara ọbara n'ime efere ọtụtụ olulu mmiri, yana akụrụngwa ụlọ nyocha na arịa dị n'azụ.

PhD: imeziwanye mmezi akpụkpọ anụ na JEB

Imezi mmezi akpụkpọ ahụ na JEB: Otu ọmụmụ a nwere ike isi kwalite ọgwụgwọ maka ụdị Epidermolysis Bullosa (EB) niile.
Mụtakwuo
Ihe atụ nke eriri DNA na-emekọrịta ihe na ụmụ irighiri ihe okirikiri ndụ ndụ, nke edobere megide nzụlite gradient.

Ọmụmụ ọnya Nanoneedle na RDEB

Choputa ihe omumu nanoneeedle ohuru na RDEB - imeputa uzo nlere anya nke na-adighi mgbu maka ogwugwo oria kacha mma na nchoputa oria cancer n'oge.
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Eserese na-egosi ebumnuche onye ọrịa na-eme nyocha ọgwụ cannabinoid sitere na mgbu na mgbu na EB, na-egosipụta ụbụrụ, akpụkpọ ahụ na akwụkwọ osisi cannabis n'akụkụ mbọ PhD lekwasịrị anya n'ịkwalite mmezi akpụkpọ ahụ na JEB.

Ọgwụ Cannabinoid maka mgbu na ọnya EB niile

Chọpụta otú ọgwụgwọ ndị dabeere na cannabinoid nwere ike isi belata mgbu na mgbu na ndị ọrịa nwere Epidermolysis Bullosa (EB).
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Onyonyo nke onye ji mbadamba nkume n'aka.

Mbadamba Psoriasis eweghachiri maka EBS

Chọpụta otú e si emepụta mbadamba nkume psoriasis maka EBS. Mụta maka uru na ihe ọ pụtara na ụzọ ọhụrụ a nwere.
Mụtakwuo
Foto eserese nke Dr Zoe Venables.

Ibi na EB na UK

Dr Zoe Venables na-eduzi oru ngo iji ghọtakwuo ka ndị mmadụ na EB si emetụta mgbaàmà ha.
Mụtakwuo
Nwata na-amụmụ ọnụ ọchị nke yi nku nru ububa na-acha anụnụ anụnụ na-ejide nku anya urukurubụba polka nwere ntụpọ pink n'ihu ọnụ ụzọ turquoise.

Na-emeso JEB na protein laminin

Chọpụta ka protein lamini nwere ike isi bụrụ isi ihe na-agwọ JEB. Mụta maka ọrụ na-akụda mmụọ na Mahadum Queen Mary, London.
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Nwata na-eji egwu egwu na-eji ngaji leba anya n'ọnụ okenye mepere emepe. Ha abụọ nọ n'ime ụlọ, na-anọdụ ala n'ihe ndina.

DEB cancer na ọnụ ọnya ọgwụgwọ

Mụta maka ihe ịma aka nke ọgwụgwọ ọnya na DEB na ikike nke mmepe ọrịa kansa.
Mụtakwuo
Igodo ahụigodo ise a haziri asụpe “PASTE” na okirikiri uhie.

Usoro ọgwụgwọ mkpụrụ ndụ na-adịgide adịgide maka DEB

Ọganihu kachasị ọhụrụ na usoro ọgwụgwọ mkpụrụ ndụ maka DEB: Dr. Joanna Jacków na-enyocha ikike maka ọgwụgwọ na-adịgide adịgide maka mgbaàmà akpụkpọ anụ DEB.
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Onye na-ere ọgwụ na-enyocha karama ọgwụ na shelf jupụtara na ngwaahịa ọgwụ dị iche iche.

Na-atụgharị statins maka RDEB kansa anụ ahụ

Chọpụta ka statins na-emegharịghachi nwere ike isi nye ọgwụgwọ ọhụrụ maka ọrịa kansa anụ ahụ RDEB. Mụta maka nchọpụta mmalite na blọọgụ onye nyocha anyị.
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Ezinụlọ na-amụmụ ọnụ ọchị na igwefoto. Otu nwata nwoke yi uwe elu DEBRA na-acha odo odo

Ngwa ahụike maka ndị nne na nna EB niile

Onye nyocha Prọfesọ Andrew Thompson na-enyocha ka ngwa ngwa enyemaka onwe onye nwere ike isi kwado ọdịmma nke ndị nne na nna nke ụmụaka nwere ụdị EB niile.
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Ihe dị nso nke ụkwụ nwa na-adabere n'aka onye toro eto na mbọ na-ese oji, na-adabere n'azụ dị nro, na-adịghị mma.

Ngwọta ọnya emelitere maka EBS

Ngwọta ọnya EBS: Chọpụta nyocha gbasara ọgwụgwọ nwere ike sitere na ndị na-akwado anyị yana blọọgụ onye nyocha.
Mụtakwuo
Mechie anya nke nwere iris na-acha aja aja, nku anya ogologo, na ngosipụta ìhè n'ahụ nwa akwụkwọ ahụ.

Anya anya maka ụdị EB niile

Mụta maka nsị anya ọhụrụ na-eji gellan gum. Mmụba ihe ọhụrụ ndị a na-achọ ibelata mgbu na ọnya na ndị ọrịa epidermolysis bullosa (EB).
Mụtakwuo
Onye na-ejide efere olulu mmiri 96 nke nwere ihe dị iche iche nwere agba dị iche iche n'ime ụlọ nyocha.

Ọgwụ nyocha iji nwalee ọrịa cancer RDEB

Ịmata ọgwụgwọ dị irè maka ọrịa kansa anụ ahụ na ndị ọrịa nwere RDEB. Mụta maka nchoputa na-ekwe nkwa nke nwere ike iduga na nnwale ụlọ ọgwụ ngwa ngwa maka ọgwụgwọ dị nchebe, nke eweghachitere.
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Eserese na-egosi usoro ọgwụgwọ ọnya: imechi site na nhazi skaab, mmụba mkpụrụ ndụ, na iweghachi anụ ahụ site na ntinye ọbara. Akara akara gụnyere epidermis, dermis, fibroblast, na macrophage.

Ọgwụgwọ ọnya na ụdị EB niile

Inyocha ọgwụgwọ ọnya n'ụdị EB niile yana ebumnuche enwere ike maka ọgwụgwọ iji belata ọnya na ihe egwu kansa na DEB.
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Ihe atụ nke onye nwere ntachu n'azụ ya, guzo n'okpuru ìhè anyanwụ. Akpụkpọ ahụ na-egosi usoro hexagonal, na-emesi ike ikpughe anyanwụ na mmetụta okpomọkụ.

KEB na ọrịa kansa anụ ahụ

Nyochaa njikọ dị n'etiti Kindler EB (KEB) na ọrịa kansa anụ ahụ wee mụta maka ọgwụgwọ ndị nwere ike ime n'ọdịnihu iji jikwaa ọnọdụ a na-adịghị ahụkebe.
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Mweghachi ọgwụ mgbochi ọnya na RDEB (2023)

Chọgharịa nyocha maka iweghachi ọgwụ na-egbu egbu iji belata fibrosis na ibelata mgbaàmà na recessive dystrophic epidermolysis bullosa (RDEB).
Mụtakwuo
Ihe atụ nke otu nwoke nwere ebe pụtara ìhè na-egosi carcinoma cell squamous n'egedege ihu ya na nso nso nke ọnya akpụkpọ ahụ.

Ọrịa cancer anụ ahụ RDEB (2023)

Ịmata ohere ọhụrụ maka mmepe ọgwụ n'ọdịnihu iji gwọọ ọrịa kansa anụ ahụ na ndị ọrịa nwere RDEB.
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Ọkpụkpụ na RDEB (2023)

Chọpụta nchọnchọ nyocha gbasara ọnyà RDEB na ikike ọ nwere ibute ọgwụgwọ ọhụrụ maka enyemaka mgbaama.
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Ịghọta ọrịa ụgbọ elu na JEB (2023)

Ịchọgharị ọgwụgwọ ọhụrụ maka ọrịa ụgbọ elu na JEB, na-achọ iweghachi iku ume site na nrụzi cellular na usoro ọgwụgwọ mkpụrụ ndụ.
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Ntinye aka na sistemu mgbochi na RDEB (2023)

Nweta nghọta ka usoro ahụ ji alụso ọrịa ọgụ si emekọrịta ihe na ọrịa ahụ yana ihe ọ pụtara maka usoro ọgwụgwọ.
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Microbiome akpụkpọ nke ụdị EB niile (2023)

Mụta maka nyocha na-emebi ala na microbiome akpụkpọ nke ụdị EB niile na 2023.
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Fesa na ọgwụgwọ mkpụrụ ndụ RDEB (2022)

Nyocha banyere iji nje nwere nkwarụ na-ebuga ndị nwere RDEB ọgwụgwọ mkpụrụ ndụ ihe nketa site na ịgba.
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Ọmụmụ ihe mgbaàmà PEBLES RDEB (2022)

Mụta maka isi ihe nchoputa nke 2022 PEBLES RDEB akara ngosi yana ihe ha pụtara maka ndị ọrịa.
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Iji EBS na-eje ije (2022)

Nnyocha na-eleba anya ka ndị nwere EBS si agbanwe ije ije na otú nke a si emetụta gait na nkwonkwo ndị ọzọ.
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Ọgwụ ịgbafe ọnụ/akpịrị (2022)

Chọpụta uru nke ọgwụgwọ ịgba ọnụ maka EB. Chọpụta ka ngwọta ọhụrụ a nwere ike isi nyere aka jikwaa mgbaàmà yana melite ogo ndụ.
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Rigosertib maka RDEB SSC (2022)

Chọpụta ike nke rigosertib maka ọgwụgwọ RDEB Skin Cancer. Nyochaa nyocha na-ekwe nkwa na ihe ọ pụtara maka ndị ọrịa.
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Mkpụrụ ndụ sistemu mgbochi na ọnya RDEB (2022)

Nyochaa mmekọrịta dị n'etiti mkpụrụ ndụ sistemu ahụ ji alụso ọrịa ọgụ na ọnya RDEB na 2022. Nweta nghọta na nyocha na ọganihu kachasị ọhụrụ na mpaghara a.
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Na-emeso DEB itching na mkpụrụ ndụ stem (2022)

Chọpụta ihe kachasị ọhụrụ na ọgwụgwọ DEB itching na 2022 site na iji ọgwụgwọ sel stem. Chọpụta ka ụzọ ọhụrụ a nwere ike isi nye ahụ efe.
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Usoro ọgwụgwọ mkpụrụ ndụ maka EBS na RDEB (2022)

Mụta maka usoro ọgwụgwọ mkpụrụ ndụ ọhụrụ kachasị ọhụrụ maka EBS na RDEB na 2022. Chọpụta ohere na-ekwe nkwa maka ọgwụgwọ ọhụrụ.
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Decorin gel iji belata ọnya (2019)

Chọpụta otú ndị na-eme nchọpụta si ele gels anya iji belata EB scarring.
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LENTICOL F (2019)

Selụ akpụkpọ anụ ndị megharịrị mkpụrụ ndụ ihe nketa nwere ike inye ọgwụgwọ bara uru maka RDEB? Ọmụmụ maka iweghachi C7 na akpụkpọ RDEB iji belata ọnya.
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Inman-South 1 (2019)

Chọpụta ka DEBRA si enweta ego nyocha n'ime ka nkesa TGF-β si enye aka na uto ọrịa kansa.
Mụtakwuo

Hickerson 1 (2019)

Site na ntinye ego DEBRA, Hickerson na-etolite ntule nhụsianya akpụkpọ ahụ iji chọpụta ihe njedebe ụlọ ọgwụ.
Mụtakwuo

McLean 12 (2019)

McLean na Hickerson mepụta nchekwa data iji nakọta genotypes nke ndị ọrịa EBS n'ime UK iji chọpụta usoro DNA.
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Brunton 1 (2018)

Brunton na-eleba anya n'ịkọwa ọrụ nke kindlin-1 na nhazi nke nkwụsi ike microtubule na mitosis na nyocha a nke DEBRA UK kwadoro.
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ADSTEM (2018)

McGrath na-enyocha ka mkpụrụ ndụ stromal mesenchymal (MSC) nwere ike isi gbanwee ogo ọrịa na ndị ọrịa nwere RDEB.
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Roopenian 2 (2017)

Roopenian na-enyocha na-achọpụta mkpụrụ ndụ ihe nketa mgbanwe na JEB nke na-emetụta ogo mgbaàmà ndị ọrịa dị iche iche nwere.
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Tolar 3 (2017)

Tolar na-enyocha iji mkpụrụ ndụ limbal limbal agwọ ọnya corneal na ndị ọrịa epidermolysis bullosa.
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Gaggioli 2 (2017)

Gaggioli kwadoro nchoputa iji mepụta ọgwụ iji gbochie ọnya na SCC na ndị ọrịa nwere EB dystrophic recessive.
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Bauer 5 (2017)

Bauer na-edu ndị otu sitere na ngalaba nyocha atọ ama ama iji nyochaa ngwaọrụ nchekwa iji tinye aka na nnwale ụlọ ọgwụ maka ndị ọrịa Nh-JEB.
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Afọ 1 (2017)

Prọfesọ Uitto na-edu otu na-enyocha ikike Amlexanox iji nwetaghachi protein COL7A1 na-efu na ndị nwere RDEB.
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O'Toole (2015)

Edel O'Toole na-edu otu iji nyochaa ka mbenata ma ọ bụ ikpochapụ ọkwa nke ColVII si emetụta mkpụrụ ndụ SCC mara mma.
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EBSTEM (2015)

McGrath na-edu otu ndị nyocha uru nke mmịnye MSC n'ime intravenous na nnwale ụlọ ọgwụ nke mmadụ iri nwere RDEB.
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Tolar 2 (2015)

Ụzọ dabere na TALEN iji zụlite ọgwụgwọ dị mma na nke dị irè maka ndị nwere EB na-eji sel sitere na ndị ọrịa RDEB.
Mụtakwuo

McLean/Heagerty 1 (2014)

Mclean na Heagerty na-eduzi ọmụmụ ihe gbasara usoro ọgwụgwọ siRNA na epidermolysis bullosa simplex (EBS).
Mụtakwuo

McGrath (2014)

McGrath na-edu otu otu iji chọpụta ntọala molekụla nke ụdị epidermolysis bullosa na-enweghị ama ugbu a.
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Sonnenberg (2013)

Sonnenberg na-edu otu otu ka ha mụọ ma kindlin-2 nwere ike kwụọ ụgwọ maka mfu nke kindlin-1 yana imegharịgharị integrin.
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Ndịda (2013)

South na-enyocha ma ọ bụrụ na igbochi PLK1 na-akwụsị ọganihu nke squamous cell carcinoma na ndị nwere RDEB.
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Ụlọ ọgbara ọhụrụ, nke nwere ọtụtụ ụlọ nwere ihe mkpuchi iko na akara na-agụ "Ụlọ nyocha ọrịa cancer." Enwere ahịhịa ahịhịa n'ihu yana mmadụ ole na ole n'akụkụ ọnụ ụzọ mbata.

Mmekọrịta: RDEB ụdị ọrịa kansa tupu ụlọọgwụ

Chọpụta mkpa ụdị ọrịa kansa RDEB tupu ụlọ ọgwụ na nyocha ọrịa kansa na mmepe ọgwụgwọ.
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Ahịhịa na-acha anụnụ anụnụ nwere "NHS" na mkpụrụedemede ọcha, etinyere n'okirikiri na-acha anụnụ anụnụ.

Mmekọrịta NHS England: Ịghọta ozi ndị ọrịa EB nwere n'ime NHS

This project will find out facts and figures about EB that can be used to raise awareness and improve treatment.
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